Downstream box: a hidden translational enhancer
نویسندگان
چکیده
منابع مشابه
mRNA poly(A) tail, a 3' enhancer of translational initiation.
To evaluate the hypothesis that the 3' poly(A) tract of mRNA plays a role in translational initiation, we constructed derivatives of pSP65 which direct the in vitro synthesis of mRNAs with different poly(A) tail lengths and compared, in reticulocyte extracts, the relative efficiencies with which such mRNAs were translated, degraded, recruited into polysomes, and assembled into messenger ribonuc...
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To investigate regulation of human immunoglobulin heavy chain expression, we have cloned DNA downstream from the two human Calpha genes, corresponding to the position in the mouse IgH cluster of a locus control region (LCR) that includes an enhancer which regulates isotype switching. Within 25 kb downstream of both the human immunoglobulin Calpha1 and Calpha2 genes we identified several segment...
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In this paper we propose that translational rate is modulated by pairs of consecutive codons or bicodons. By a statistical analysis of coding sequences, associated with low or with high abundant proteins, we found some bicodons with significant preference usage for either of these sets. These usage preferences cannot be explained by the frequency usage of the single codons. We compute a pause p...
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Geometric covering problems are found in application domains such as sensor coverage and repairing of materials. This paper considers covering problems in which a target shape to be covered is specified and a set of covering shapes is supplied. The goal is to find translational positions of the covering shapes that allow them to collectively cover the target. All the shapes are orthotopes (conv...
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ACKNOWLEDGMENTS Sir , this thesis is dedicated to you.
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ژورنال
عنوان ژورنال: Molecular Microbiology
سال: 1998
ISSN: 0950-382X,1365-2958
DOI: 10.1046/j.1365-2958.1998.00730.x